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Доповіді НАН України. – 2008. – N 9. – С. 167–172.
Функціонування ферментів антиоксидантного захисту в клітинах слизової оболонки шлунка за умов виразкової патології при введенні омепразолу
Л.І. Кот, О.В. Богданова, А.Д. Рахметов, Л.І. Остапченко
Abstract
Superoxide dismutase, catalase, glutathione peroxidase activities in stomach
mucosa cells in rats are evaluated with an experimental stress model of
ulcer development and healing during five days. These parameters are also
investigated under omeprazole treatment. It is established that the mucosa
regeneration process is accompanied by superoxide dismutase activation and
inhibition of glutathione peroxidase activity. Omeprazole treatment induced
a prompt increase of the superoxide dismutase activity and a decrease of the
catalase and glutathione peroxidase activities. Under conditions of
omeprazole injections of unstressed rats, the superoxide dismutase activity
was not changed. The inhibition of the catalase and glutathione peroxidase
activities after drug treatment is observed.
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