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Доповіді НАН України. – 2008. – N 9. – С. 141–145.
Іммобілізація бактерицидних речовин на поверхні целюлозних мембран, модифікованих полігліцидилметакрилатом
О.О. Чикетa, Г.А. Побігай, В.В. Коновалова, А.Ф. Бурбан
Abstract
The method of modification of ultrafiltration cellulose membranes by
glycidylmethacrylate (GMA) with the next immobilization of nalidixic acid
and levofloxacin on them has been developed. Transport and antimicrobial
properties of modified membranes have been studied. A decrease of the
permeability caused by the grafting of GMA is shown. Antibacterial
properties of membrane samples modified by antibiotics are studied against
gram-negative bacteria E. coli and gram-positive bacteria S. aureus. Higher
antibacterial activity of membranes modified by levofloxacin in comparison
with those modified by nalidixic acid is shown. Thus, the antibacterial
activity of membranes modified by 0.5% solutions of antibiotics
was 90% for samples with nalidixic acid and 100% for samples
with levofloxacin. All samples showed a lower antibacterial activity
against that of gram-negative bacteria. The antibacterial activity remains
stable for 36 days.
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