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Доповіді НАН України. – 2008. – N 3. – С. 145–148.
Експресія гена RET в післячорнобильських пухлинах щитовидної залози
Л.Г. Воскобойник, Т.І. Богданова, М.Д. Тронько
Abstract
The expression of RET gene that encodes a transmembrane receptor with
tyrosine kinase activity, was studied on 59 post-Chernobyl thyroid tumors
(35 papillary carcinomas and 24 follicular adenomas). It is shown that the
majority of tumors, both benign and malignant, exhibits RET expression. The
presence of gene RET in thyroid tumors was not associated with their
histological structure, invasiveness, tumor's sizes, and the age and sex of
patients. Nevertheless, the occurrence of RET expression (which is not
expressed in normal thyroid cells) in the great part of post-Chernobyl
thyroid tumors suggests a potential role of RET in the development of
thyroid neoplasms, both benign and malignant.
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