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Доповіді НАН України. – 2008. – N 2. – С. 174–177.
Участь МАРК в опосередкуванні дії протипухлинного препарату таксолу на клітини анапластичного раку щитовидної залози
І.Д. Попадюк, В.М. Пушкарьов, Н.М. Костюченко, М.Д. Тронько
Abstract
The role of MAPK (mitogen-activated protein kinase) in mediating the action
of antitumour drug taxol on the cell line of thyroid anaplastic cancer, ARO,
is studied. It is shown that taxol enhances the phosphorylation of
anti-apoptotic protein Bcl-2 and activated the main executioner caspase-3.
Taxol did not activate р38 МАРК but significantly inhibits the activation of
ERK1/2, another MAP kinase that participates in survival mechanisms.
The possible factor under control of this kinase can be a protein-inhibitor of
apoptosis, XIAP. This suggestion is confirmed by experiments with the inhibitor
of c-Raf-1/MEK1/ERK cascade, PD98059. In the presence of the inhibitor, the
XIAP quantity essentially decreased as well as the cell viability.
The possible means of augmentation of the taxol cancerostatic effect upon
thyroid cancer cells are discussed.
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